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Standardized Pharmaco-EEG in Clinical Development
Pharmaco-EEG measures the direct and indirect effects of active compounds on brain activity to evaluate a drug's pharmacodynamic (PD) and pharmacokinetic (PK) properties, its CNS penetration, and its potential therapeutic or toxic effects. By employing standardized methodologies, pharmaco-EEG can serve as a translational biomarker, bridging preclinical research and clinical drug development and aiding in the evaluation of CNS-active compounds in humans.